MakroActive
Colostrum & bacterial culture mixture in gastro-resistant capsule
Orderable
- Free of dyes
- Gluten-free
- Preservative-free as required by law
- Lactose-free
- Free of anti-caking and binding agents
| Price Tiers |
| from 1 Pieces | 59,95 € |
| from 3 Pieces | 53,95 € |
| from 5 Pieces | 50,95 € |
NatuGena MacroActive – Contains 6 distinct non-histamine- producing bacterial strains with a total of 44 billion live cultures per daily dose. The formula is enriched with vitamin A, D3 and K2, premium colostrum (30% IgA), and chondroitin sulphate. Free from additives and lactose, manufactured in Germany, and delivered in gastro-resistant capsules. One pack contains 90 capsules for a 30-day supply.
- High-potency bacterial strains: Combines six non-histamine-producing lactic acid bacteria in a potent concentration of 44 billion colony-forming units (CFU)
- Highly concentrated colostrum: With 30% immunoglobulin A (IgA) content
- Premium colostrum quality: Ethically sourced from pasture-raised cows and gently freeze-dried for maximum purity
- Vitamins per daily dose: 2,000 IU vitamin D3, 200 μg vitamin K2 and 1,500 IU vitamin A per daily dosage
- Made in Germany: Exceptional purity and bioavailability for optimal nutrient uptake

What is MacroActive, and what makes its ingredients unique?
MacroActive is a synergistic formulation combining non-histamine-forming lactic acid bacteria, colostrum, and essential vitamins. The included vitamins A and D contribute to the normal function of the immune system. The six precisely selected strains, totalling 44 billion live cultures per daily dose, help maintain a balanced gut microbiota. The capsules are made from cellulose and are gastro-resistant, protecting the bacterial strains from stomach acid and ensuring their release in the intestines.
Why Are the Bacterial Strains Considered Low in Histamine?
Not all bacterial strains benefit the gut equally. The six strains in MacroActive have been selected specifically because they do not produce histamine, making the product suitable for individuals sensitive to histamine-rich foods.

What Role Do the Included Vitamins Play?
Vitamin A and D contribute to the normal function of the immune system. Each daily dosage contains 50 μg (2.000 IE) Vitamin D3, 450 μg RE (1.500 IE) Vitamin A and 200 µg Vitamin K2. These fat-soluble vitamins are formulated with oleic acid as a carrier to enhance absorption and bioavailability.
Why Is Colostrum a Valuable Ingredient?
Colostrum, also known as first milk or foremilk, is naturally rich in vitamins, minerals, enzymes, and amino acids. MacroActive uses only ethically sourced surplus colostrum from well-treated cows. The product is virtually lactose-free (<0.01 g/100 g) thanks to natural lactose reduction and is gently freeze-dried to preserve its valuable bioactive components.
What Is the Role of Chondroitin Sulphate?
Chondroitin sulphate (bovine-derived) is a key structural component of cartilage, connective tissue, and bones. In this formula, it complements the overall support for structural integrity.
Quality
- No separating agents, binding agents or colourants
- Free from genetic engineering, nanoparticles and animal testing
- Hypoallergenic and sensitive formulations (e.g. free from lactose, soya and gluten where possible)
- Ultra-pure, plant-based coating agents (HPMC) and food-safe, light-protected containers
- Free from unwanted additives such as PEG, silicon dioxide, magnesium stearate & titanium dioxide
- Premium raw materials from pure substances
- Regular, independent testing for harmful substances
- Production in accordance with German quality standards (GMP, HACCP, ISO 9001)
Recommended Consumption
3 capsules once a day. For best results, take at least 15 minutes before a meal with 250 ml of still, lukewarm water or, alternatively, with a teaspoon of omega-3 oil to increase bioavailability.
Notes
Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of small children. Store in a cool, dry place away from light. Do not exceed the recommended daily intake. Not suitable for pregnant or breastfeeding women, children and adolescents, or people taking anticoagulants.
Content
| Ingredients per | daily dose | NRV¹ | IE² |
|---|---|---|---|
| Chondroitin sulphate | 180 mg | ||
| Colostrum | 400 mg | ||
| – of which immunglobulin | 120 mg | ||
| Bacterial mixture | 44 × 10⁹ CFU³ | ||
| Vitamin A (RE) | 450 µg | 56 | 1499 |
| Vitamin D3 | 50 µg | 1000 | 2000 |
| Vitamin K2 (MK-7) | 200 µg | 268 |
1 Reference amounts for the average adult according to Regulation (EU) No 1169/2011 (in %).
2 International units
3 Colony-forming units
Composition
Colostrum (from cow’s milk, 30% IgG), enteric-coated Coating agent: hydroxypropyl methylcellulose (HPMC); chondroitin sulphate, MCT powder, bacterial mixture (Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium bifidum, Lactobacillus acidophilus, Lactococcus lactis, Bifidobacterium longum), vitamin K2 (MK-7, all-trans), retinyl acetate, cholecalciferol.
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Read moreFAQ
Most of our capsules can be opened without any concerns. The contents can be stirred into yogurt, plant-based yogurt, applesauce, smoothies, or juice, for example.
One of the reasons we encapsulate the ingredients is to keep their sometimes intense natural taste and smell as neutral as possible. When opened, the taste and smell may therefore be more noticeable.
Did you know? Our capsules can be easily opened by gently twisting them.
Please do not open: enteric-coated capsules
For certain bacterial and enzyme products, we use enteric-coated capsules. These should not be opened, as doing so may alter the intended release profile.
These include, for example:
- Bacterial preparations, such as HistaBakt, MakroAktiv, and BactoGena 21+2
- Enzyme products, such as N-Zymarase® Intest and N-Zymarase® Inflam. Exception: N-Zymarase Komplex contains betaine HCl, which is intended to take effect in the stomach; therefore, it does not have an enteric-coated capsule shell and can be opened
- Soft capsules with liquid contents, such as omega-3 capsules, are also not intended to be opened. In this case, you can switch to the liquid oil instead.
If you have any questions, please contact our advisory team at info@natugena.de.
From the very beginning, NatuGena has used exceptionally pure, plant-based HPMC capsules in the majority of its products. HPMC stands for hydroxypropyl methylcellulose and is made from plant-based cellulose.
Unlike many HPMC capsules commonly available on the market, the coating agents we use contain no carrageenan or PEG. Although they are more expensive, they meet our high standards for a carefully selected and transparent product composition.
Our plant-based HPMC capsules are:
- 100% plant-based cellulose (HPMC)
- Carrageenan-free
- PEG-free
- Gelatin-free
- GMO-free
- Free of allergens and irritants
What types of capsule shells are used in omega-3 products?
Special softgels are required for liquid oils. Our classic omega-3 capsules therefore contain a coating made from gelatin and glycerin and are not vegan.
In our vegan omega-3 capsules made from algae oil, the coating consists of glycerin and modified cornstarch and contains no gelatin. This makes these capsules suitable for a vegan diet.
The exact composition of each coating agent is clearly listed in the ingredients list.
It All Comes Down to the Composition
Conventional capsule shells may contain technical additives—such as anti-caking agents, release agents, or binders—due to the manufacturing process. These components aren’t always immediately apparent, as certain processing aids aren’t required to be listed in the ingredients list.
Most of the NatuGena capsule products are size 00 (8,2 × 23,3 mm) to 0 (7,3 × 21,2 mm). Information on the capsule sizes of individual products can be found on the relevant product page or by contacting info@natugena.de
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|---|---|---|---|---|---|
| 9,5 × 26,1 mm | 8,2 × 23,3 mm | 7,3 × 21,2 mm | 6,6 × 19,0 mm | 6,1 × 17,3 mm | 5,6 × 15,4 mm |
| z. B. Lysin & Vitamin C, Monacolin K 3 |
z. B. Magnesia 7+1, MitochondrienAktivator 44+14, HeparAktiv |
z. B. ZellEnergie, MultiVegan, Astaxanthin |
z. B. HistaBakt, Bor, Bioaktiver B-Komplex |
not in use | z. B. Kupfer, LipoVitamine 10 000, Mangan-Komplex |
We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.
In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.
For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.
The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.
There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.
In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.
The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.
In the morning
Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:
- Coenzyme Q10
- Green tea extract
- Certain B vitamins
Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.
Throughout the day
For some nutrients, it may be beneficial to divide the daily amount into several doses.
Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.
Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.
In the evening
Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.
In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.
With a meal
Some nutrients benefit from being taken together with a meal.
Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.
Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.
Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.
Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.
Between meals
Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:
- Coffee and tea
- Caffeinated beverages
- Milk and dairy products
- Calcium- or mineral-rich supplements
However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.
Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.
Around exercise
Proteins and amino acids can be taken both before and after training.
If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.
In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.
If you need this item on a long-term basis and are interested in a discounted subscription, you can find the terms and conditions on the Product Subscription page.
Country-specific information
This item may not be resold in the following countries: Switzerland
Legal notice
This product is for nutritional purposes and therefore does not affect the Heilmittelwerbegesetz (HWG). Good nutritional status is important for your general well-being. All statements made about the product describe properties and physiological effects that may naturally vary among consumers and do not represent any healing or health promises.
Responsible person for the EU
The economic operator based in the EU responsible for this product:
NatuGena GmbH, Münchener Str. 149, 85051 Ingolstadt, Germany,
+49 841 90 255 000, info@natugena.de, https://www.natugena.de





