Saffron-2-Complex
Saffron extracts and magnesium
Orderable
- Free of dyes
- Gluten-free
- Preservative-free as required by law
- Lactose-free
- Vegan
- Free of anti-caking and binding agents
| Price Tiers |
| from 1 Pieces | 44,95 € |
| from 3 Pieces | 40,95 € |
| from 5 Pieces | 38,95 € |
NatuGena Saffron-2-Complex – Saffron, one of the most precious spices in the world, is obtained from the delicate stigmas of the saffron crocus (Crocus sativus). The capsules contain the premium branded ingredient Saffr’Activ®. Additionally enriched with magnesium, vitamin B12, and the branded ingredient Probiostress™. 60 vegan capsules provide a 30-day supply.
- Precious spice: Saffron is often referred to as "red gold"
- Patented saffron extract: Saffr‘Activ® from France, derived from the finest parts of the red stigmas of Crocus sativus
- Standardised saffron extract: Contains at least 3% crocins and 2% safranal
- Branded ingredient Probiostress™: Combines lacto- and bifidobacteria with saffron extract

Saffron is considered the most noble, valuable, and expensive spice in the world. This aromatic spice is prized for its unique flavour and vibrant golden-yellow colour. It is not only used in cooking but has also held a prominent place in traditional plant knowledge across various cultures for centuries. The history of saffron can be traced back to ancient times, including its use in Mesopotamian culture. Today, saffron is primarily cultivated in countries such as Iran, Spain, India, and Greece.
How is saffron harvested?
Saffron is obtained from the delicate stigmas of the saffron crocus (Crocus sativus). Harvesting these threads is carried out entirely by hand and is extremely labour-intensive, as each flower produces only three of these precious stigmas. It takes approximately 150 000 flowers to produce one kilogram of saffron, making it one of the rarest and most expensive spices in the world. Saffron quality is assessed by its colour intensity, with crocin content being responsible for the colouring. Often referred to as "red gold", saffron holds a unique position in the culinary world due to its distinctive properties.

What makes Saffr‘Activ® special?
Saffr‘Activ® is a patented saffron extract from France, derived from the finest parts of the red stigmas of Crocus sativus. This uniquely standardised extract contains at least 3% crocins and at least 2% safranal. Crocins are water-soluble carotenoids responsible for the yellow colour of saffron. Safranal, a monoterpene aldehyde, gives saffron its characteristic aroma. Saffr‘Activ® guarantees 100% purity and is free from GMOs, pesticides, allergens, and heavy metals.
How do magnesium and vitamin B12 support the Saffron-2-Complex?
Saffron-2-Complex is enriched with magnesium and vitamin B12. The vitamin B12 is present in the bioactive forms hydroxocobalamin and methylcobalamin, meaning it can be absorbed and used by the body directly without requiring conversion. Magnesium and vitamin B12 support energy metabolism, contribute to normal nervous system function, and help reduce tiredness and fatigue.
What is Probiostress™?
Probiostress™ is a combination of lactobacilli, bifidobacteria, and saffron extract. This formulation contains a stable blend of saffron extract (Saffr‘Activ®) and two probiotic strains: Lactobacillus reuteri and Bifidobacterium breve. These ingredients have been carefully selected to support the balance of intestinal flora. The saffron extract used is valued for its quality and purity.
Quality
- No separating agents, binding agents or colourants
- Free from genetic engineering, nanoparticles and animal testing
- Hypoallergenic and sensitive formulations (e.g. free from lactose, soya and gluten where possible)
- Ultra-pure, plant-based coating agents (HPMC) and food-safe, light-protected containers
- Free from unwanted additives such as PEG, silicon dioxide, magnesium stearate & titanium dioxide
- Premium raw materials from pure substances
- Regular, independent testing for harmful substances
- Production in accordance with German quality standards (GMP, HACCP, ISO 9001)
Recommended Consumption
2 capsules once a day. For best results, take with a high-fat meal, with 250 ml of still, lukewarm water or, alternatively, with a teaspoon of omega-3 oil to increase bioavailability.
Notes
Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of small children. Store in a cool, dry place away from light. Do not exceed the recommended daily intake.
Content
| Ingredients per | Daily dose (2 capsules) | NRV¹ |
|---|---|---|
| Magnesium | 150 mg | 40 |
| Probiostress™² | 500 mg | |
| – of which Lactobacillus and Bifidobacterium cultures | 3 billion CFU³ | |
| – of which saffron extract | 30 mg | |
| Saffr‘Activ® saffron extract (1.5–3:1)⁴ | 15 mg | |
| – of which crocin | 450 μg | |
| Vitamin B12 | 20 μg | |
| – of which hydroxocobalamin (bioactive) | 10 μg | 400 |
| – of which methylcobalamin (bioactive) | 10 μg | 400 |
1 Nutrient Reference Values (NRV) for the average adult according to Regulation (EU) No. 1169/2011 (in %).
2 Probiostress™ is a trademark of Comercial Quimica Massó SA.
3 Colony-forming units (CFU).
4 Saffr‘Activ® is a trademark of Comercial Quimica Massó SA.
Composition
Magnesium bisglycinate, Probiostress™ (corn starch; saffron extract; bacterial cultures (Lactobacillus helveticus, Bifidobacterium longum), coating agent: hydroxypropyl methylcellulose (HPMC)); Saffr‘Activ® saffron extract, hydroxocobalamin, methylcobalamin.
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Read moreFAQ
Most of our capsules can be opened without any concerns. The contents can be stirred into yogurt, plant-based yogurt, applesauce, smoothies, or juice, for example.
One of the reasons we encapsulate the ingredients is to keep their sometimes intense natural taste and smell as neutral as possible. When opened, the taste and smell may therefore be more noticeable.
Did you know? Our capsules can be easily opened by gently twisting them.
Please do not open: enteric-coated capsules
For certain bacterial and enzyme products, we use enteric-coated capsules. These should not be opened, as doing so may alter the intended release profile.
These include, for example:
- Bacterial preparations, such as HistaBakt, MakroAktiv, and BactoGena 21+2
- Enzyme products, such as N-Zymarase® Intest and N-Zymarase® Inflam. Exception: N-Zymarase Komplex contains betaine HCl, which is intended to take effect in the stomach; therefore, it does not have an enteric-coated capsule shell and can be opened
- Soft capsules with liquid contents, such as omega-3 capsules, are also not intended to be opened. In this case, you can switch to the liquid oil instead.
If you have any questions, please contact our advisory team at info@natugena.de.
From the very beginning, NatuGena has used exceptionally pure, plant-based HPMC capsules in the majority of its products. HPMC stands for hydroxypropyl methylcellulose and is made from plant-based cellulose.
Unlike many HPMC capsules commonly available on the market, the coating agents we use contain no carrageenan or PEG. Although they are more expensive, they meet our high standards for a carefully selected and transparent product composition.
Our plant-based HPMC capsules are:
- 100% plant-based cellulose (HPMC)
- Carrageenan-free
- PEG-free
- Gelatin-free
- GMO-free
- Free of allergens and irritants
What types of capsule shells are used in omega-3 products?
Special softgels are required for liquid oils. Our classic omega-3 capsules therefore contain a coating made from gelatin and glycerin and are not vegan.
In our vegan omega-3 capsules made from algae oil, the coating consists of glycerin and modified cornstarch and contains no gelatin. This makes these capsules suitable for a vegan diet.
The exact composition of each coating agent is clearly listed in the ingredients list.
It All Comes Down to the Composition
Conventional capsule shells may contain technical additives—such as anti-caking agents, release agents, or binders—due to the manufacturing process. These components aren’t always immediately apparent, as certain processing aids aren’t required to be listed in the ingredients list.
Most of the NatuGena capsule products are size 00 (8,2 × 23,3 mm) to 0 (7,3 × 21,2 mm). Information on the capsule sizes of individual products can be found on the relevant product page or by contacting info@natugena.de
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|---|---|---|---|---|---|
| 9,5 × 26,1 mm | 8,2 × 23,3 mm | 7,3 × 21,2 mm | 6,6 × 19,0 mm | 6,1 × 17,3 mm | 5,6 × 15,4 mm |
| z. B. Lysin & Vitamin C, Monacolin K 3 |
z. B. Magnesia 7+1, MitochondrienAktivator 44+14, HeparAktiv |
z. B. ZellEnergie, MultiVegan, Astaxanthin |
z. B. HistaBakt, Bor, Bioaktiver B-Komplex |
not in use | z. B. Kupfer, LipoVitamine 10 000, Mangan-Komplex |
We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.
In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.
For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.
The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.
There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.
In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.
The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.
In the morning
Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:
- Coenzyme Q10
- Green tea extract
- Certain B vitamins
Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.
Throughout the day
For some nutrients, it may be beneficial to divide the daily amount into several doses.
Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.
Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.
In the evening
Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.
In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.
With a meal
Some nutrients benefit from being taken together with a meal.
Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.
Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.
Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.
Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.
Between meals
Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:
- Coffee and tea
- Caffeinated beverages
- Milk and dairy products
- Calcium- or mineral-rich supplements
However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.
Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.
Around exercise
Proteins and amino acids can be taken both before and after training.
If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.
In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.
If you need this item on a long-term basis and are interested in a discounted subscription, you can find the terms and conditions on the Product Subscription page.
Country-specific information
This item may not be resold in the following countries: Switzerland
Legal notice
This product is for nutritional purposes and therefore does not affect the Heilmittelwerbegesetz (HWG). Good nutritional status is important for your general well-being. All statements made about the product describe properties and physiological effects that may naturally vary among consumers and do not represent any healing or health promises.
Responsible person for the EU
The economic operator based in the EU responsible for this product:
NatuGena GmbH, Münchener Str. 149, 85051 Ingolstadt, Germany,
+49 841 90 255 000, info@natugena.de, https://www.natugena.de





