NRF2 Aktivator
Quercetin, Sulforaphane, Trans-Resveratrol
Orderable
- Free of dyes
- Gluten-free
- Preservative-free as required by law
- Lactose-free
- Vegan
- Free of anti-caking and binding agents
| Price Tiers |
| from 1 Pieces | 49,95 € |
| from 3 Pieces | 44,95 € |
| from 5 Pieces | 42,95 € |
NatuGena NRF2 Activator – Polyphenol blend from high-quality plant extracts with natural bioactive compounds such as sulforaphane, quercetin, catechins and trans-resveratrol. The formula is based on proven botanical sources such as broccoli, green tea, turmeric, pomegranate, milk thistle, griffonia, Japanese knotweed and Japanese pagoda tree. Supplemented with piperine from black pepper to round off the formulation. Vegan and gluten-free, with 90 Capsules for a 30-days-supply.
- Broccoli extract: Source of sulforaphane, known from cruciferous vegetables
- Green tea: Provides catechins and additional bitter compounds
- Turmeric & milk thistle: Contain bioactive compounds such as curcuminoids and silymarin
- Japanese knotweed: Natural trans-resveratrol from a traditional source
- Japanese pagoda tree: Provides quercetin – a typical flavonoid of plant origin
- Pomegranate extract: Rich in polyphenols, derived from the peel
- Griffonia simplicifolia: Plant component from West African regions
- Black pepper: Organic piperine to complement the overall formula
- Produced in Germany: Exceptional purity and bioavailability for optimal nutrient uptake


What role does the NRF2 signalling pathway play in the body?
Our bodies are challenged every day. Metabolic processes run continuously, cells work, renew themselves and constantly adapt to new situations. In the process, so-called free radicals are naturally formed. However, free radicals are not inherently harmful to the body. They are part of normal cellular activity. What matters is balance, as both their formation and their regulation are firmly anchored in physiological processes. When this balance is disrupted, the condition is referred to as oxidative stress.
To detect such changes, the body relies on finely tuned regulatory mechanisms. One of these is the so-called KEAP1-NRF2 signalling pathway. It functions like an internal sensor, detecting changes in cellular conditions, for example due to external influences or metabolic processes.

When such a state is recognised, the protein NRF2 changes its position within the cell and influences specific intracellular processes. These mechanisms are part of the body’s natural regulation of the cellular environment and help the organism adapt to different situations. The NRF2 signalling pathway is therefore part of the body’s intrinsic regulatory system and not an isolated switch, but rather integrated into a complex network of cellular processes.
Which plant compounds are included?
Numerous phytonutrients such as sulforaphane, quercetin or resveratrol are found in everyday foods – from broccoli to tea, pomegranate or onions. The included plant extracts are carefully selected and standardised. Broccoli provides sulforaphane, a secondary plant compound that the plant itself produces as a natural defence substance and which has been extensively studied in scientific research. Turmeric provides curcuminoids, milk thistle adds silymarin. Quercetin comes from the Japanese pagoda tree, trans-resveratrol from Japanese knotweed. The formulation is complemented by Griffonia simplicifolia, pomegranate extract and piperine, a compound from black pepper that is well known as a component of various spices.
Quality
- No separating agents, binding agents or colourants
- Free from genetic engineering, nanoparticles and animal testing
- Hypoallergenic and sensitive formulations (e.g. free from lactose, soya and gluten where possible)
- Ultra-pure, plant-based coating agents (HPMC) and food-safe, light-protected containers
- Free from unwanted additives such as PEG, silicon dioxide, magnesium stearate & titanium dioxide
- Premium raw materials from pure substances
- Regular, independent testing for harmful substances
- Production in accordance with German quality standards (GMP, HACCP, ISO 9001)
Recommended Consumption
Consumption recommendation
1 times a day 3 capsules. Optimal consumption is at least 15 minutes before a meal with 250 ml of still, lukewarm water.
According to REGULATION (EU) 2022/2340 recommended intake (differs from the label): 1 time daily 3 capsules. Optimal consumption is with a high-fat meal with 250 ml of still, lukewarm water or optionally with a teaspoon of omega-3 oil to increase bioavailability.
Notes
Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of small children. Store closed, in a cool, dry place away from light. Do not exceed the recommended daily intake stated. Should not be consumed on an empty stomach and on the same day with other green tea products1. Not suitable for pregnant women, nursing mothers and children under 18 years1.
1 according to REGULATION (EU) 2022/2340
Content
| Ingredients per | Daily dose |
|---|---|
| Broccoli- Extract | 1 000 mg |
| - of which sulforaphane | 100 mg |
| Pomegranate- Extract | 250 mg |
| - of which ellagic acid | 100 mg |
| Green Tea- Extract | 223 mg |
| - of which polyphenols | 219 mg |
| - of which catechins | 145 mg |
| - of which EGCG | 100 mg |
| Quercetin | 150 mg |
| Marythistle extract | 125 mg |
| - of which silymarin | 100 mg |
| Curcuma- Extract | 105 mg |
| - of which curcuminoids | 100 mg |
| Trans- Resveratrol | 100 mg |
| Piperine (organic) | 30 mg |
Composition
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Read moreFAQ
Most of our capsules can be opened without any concerns. The contents can be stirred into yogurt, plant-based yogurt, applesauce, smoothies, or juice, for example.
One of the reasons we encapsulate the ingredients is to keep their sometimes intense natural taste and smell as neutral as possible. When opened, the taste and smell may therefore be more noticeable.
Did you know? Our capsules can be easily opened by gently twisting them.
Please do not open: enteric-coated capsules
For certain bacterial and enzyme products, we use enteric-coated capsules. These should not be opened, as doing so may alter the intended release profile.
These include, for example:
- Bacterial preparations, such as HistaBakt, MakroAktiv, and BactoGena 21+2
- Enzyme products, such as N-Zymarase® Intest and N-Zymarase® Inflam. Exception: N-Zymarase Komplex contains betaine HCl, which is intended to take effect in the stomach; therefore, it does not have an enteric-coated capsule shell and can be opened
- Soft capsules with liquid contents, such as omega-3 capsules, are also not intended to be opened. In this case, you can switch to the liquid oil instead.
If you have any questions, please contact our advisory team at info@natugena.de.
From the very beginning, NatuGena has used exceptionally pure, plant-based HPMC capsules in the majority of its products. HPMC stands for hydroxypropyl methylcellulose and is made from plant-based cellulose.
Unlike many HPMC capsules commonly available on the market, the coating agents we use contain no carrageenan or PEG. Although they are more expensive, they meet our high standards for a carefully selected and transparent product composition.
Our plant-based HPMC capsules are:
- 100% plant-based cellulose (HPMC)
- Carrageenan-free
- PEG-free
- Gelatin-free
- GMO-free
- Free of allergens and irritants
What types of capsule shells are used in omega-3 products?
Special softgels are required for liquid oils. Our classic omega-3 capsules therefore contain a coating made from gelatin and glycerin and are not vegan.
In our vegan omega-3 capsules made from algae oil, the coating consists of glycerin and modified cornstarch and contains no gelatin. This makes these capsules suitable for a vegan diet.
The exact composition of each coating agent is clearly listed in the ingredients list.
It All Comes Down to the Composition
Conventional capsule shells may contain technical additives—such as anti-caking agents, release agents, or binders—due to the manufacturing process. These components aren’t always immediately apparent, as certain processing aids aren’t required to be listed in the ingredients list.
Most of the NatuGena capsule products are size 00 (8,2 × 23,3 mm) to 0 (7,3 × 21,2 mm). Information on the capsule sizes of individual products can be found on the relevant product page or by contacting info@natugena.de
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|---|---|---|---|---|---|
| 9,5 × 26,1 mm | 8,2 × 23,3 mm | 7,3 × 21,2 mm | 6,6 × 19,0 mm | 6,1 × 17,3 mm | 5,6 × 15,4 mm |
| z. B. Lysin & Vitamin C, Monacolin K 3 |
z. B. Magnesia 7+1, MitochondrienAktivator 44+14, HeparAktiv |
z. B. ZellEnergie, MultiVegan, Astaxanthin |
z. B. HistaBakt, Bor, Bioaktiver B-Komplex |
not in use | z. B. Kupfer, LipoVitamine 10 000, Mangan-Komplex |
We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.
In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.
For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.
The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.
There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.
In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.
The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.
In the morning
Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:
- Coenzyme Q10
- Green tea extract
- Certain B vitamins
Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.
Throughout the day
For some nutrients, it may be beneficial to divide the daily amount into several doses.
Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.
Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.
In the evening
Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.
In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.
With a meal
Some nutrients benefit from being taken together with a meal.
Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.
Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.
Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.
Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.
Between meals
Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:
- Coffee and tea
- Caffeinated beverages
- Milk and dairy products
- Calcium- or mineral-rich supplements
However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.
Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.
Around exercise
Proteins and amino acids can be taken both before and after training.
If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.
In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.
If you need this item on a long-term basis and are interested in a discounted subscription, you can find the terms and conditions on the Product Subscription page.
Country-specific information
This item may not be resold in the following countries: Switzerland
Legal notice
This product is for nutritional purposes and therefore does not affect the Heilmittelwerbegesetz (HWG). Good nutritional status is important for your general well-being. All statements made about the product describe properties and physiological effects that may naturally vary among consumers and do not represent any healing or health promises.
Responsible person for the EU
The economic operator based in the EU responsible for this product:
NatuGena GmbH, Münchener Str. 149, 85051 Ingolstadt, Germany,
+49 841 90 255 000, info@natugena.de, https://www.natugena.de





