Yes, the nucleotides contained in Nucleotide Modulator are derived from yeast.

Nucleotides contain natural building blocks that can be involved in the body’s purine metabolism, among other processes. Purines are broken down into uric acid in the body. Therefore, it may be advisable for individuals with a sensitive metabolic profile to monitor their individual uric acid levels.

Tolerance may vary from person to person and depends, among other factors, on diet, metabolism, kidney function, and other products or medications being taken.

If you have any concerns, we recommend consulting your doctor or therapist before use. Dietary supplements are not a substitute for a balanced diet or medical evaluation.

NucleotideModulator contains nucleotides derived from yeast. Yeast is a natural source of certain cellular building blocks, including nucleotides.

Uric acid

Histamine

Since the nucleotides are derived from yeast, individual tolerance may vary among histamine-sensitive individuals. Even though this is not a traditional fermented food, highly sensitive individuals may react differently to yeast-based ingredients. In such cases, it is advisable to start cautiously and monitor personal tolerance.

Overall tolerance depends on various factors, including diet, metabolism, gut flora, kidney function, and other products or medications being taken.

If you have any concerns, we recommend consulting your doctor or therapist before consumption. Dietary supplements are not a substitute for a balanced diet or medical evaluation.

Most of the NatuGena capsule products are size 00 (8,2 × 23,3 mm) to 0 (7,3 × 21,2 mm). Information on the capsule sizes of individual products can be found on the relevant product page or by contacting info@natugena.de

NatuGena® capsule sizes – for comparison and understanding.

9,5 × 26,1 mm	8,2 × 23,3 mm	7,3 × 21,2 mm	6,6 × 19,0 mm	6,1 × 17,3 mm	5,6 × 15,4 mm
z. B. Lysin & Vitamin C, Monacolin K 3	z. B. Magnesia 7+1, Mitochondrien­Aktivator 44+14, HeparAktiv	z. B. ZellEnergie, MultiVegan, Astaxanthin	z. B. HistaBakt, Bor, Bioaktiver B-Komplex	not in use	z. B. Kupfer, Lipo­Vitamine 10 000, Mangan-Komplex

We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.

In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.

For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.

The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.

There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.

In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.

The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.

In the morning

Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:

• Coenzyme Q10
• Green tea extract
• Certain B vitamins

Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.

Throughout the day

For some nutrients, it may be beneficial to divide the daily amount into several doses.

Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.

Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.

In the evening

Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.

In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.

With a meal

Some nutrients benefit from being taken together with a meal.

Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.

Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.

Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.

Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.

Between meals

Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:

• Coffee and tea
• Caffeinated beverages
• Milk and dairy products
• Calcium- or mineral-rich supplements

However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.

Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.

Around exercise

Proteins and amino acids can be taken both before and after training.

If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.

In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.