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HomocysteineModulator

Betaine anhydrous (TMG), SAMe & B vitamins
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Nutritional Supplement

90 capsules for 90 days

Combines betaine anhydrous (TMG), SAMe, and B vitamins to support normal homocysteine metabolism.
 

34,95
Quantity Price
from 134,95 €
from 331,95 €
from 529,95 €
Orderable
Delivery time 3–5 workdays Article No.: 2018215
PPN/PZN: 11 19679738 20 (PZN = middle digits)
EAN: 4260633572152
base price: 34,95 € per Kilogramm
incl. 7% VAT, plus shipping costs

NatuGena Homocysteine Modulator – A premium food supplement combining betaine anhydrous (TMG), SAMe and B vitamins in a synergistic formula.
The capsules contain highly bioavailable nutrients to support optimal absorption. 90 capsules for a 3-month supply.

  • Betaine and SAMe: Provides 700 mg of high-strength betaine and 20 mg SAMe per daily serving
  • B vitamins: Includes the bioactive forms of vitamins B6, B12 and folate
  • Fast absorption: Bioavailable nutrients for rapid and efficient uptake
  • Homocysteine support: B6, B12 and folate contribute to the maintenance of normal homocysteine metabolism
  • Produced in Germany: Exceptional purity and bioavailability for optimal nutrient uptake

Homocysteine Modulator contains 700 mg of high-dose betaine, which contributes to the normal metabolism of homocysteine. Homocysteine is an amino acid naturally formed in the body during the breakdown of methionine – an essential amino acid found in protein-rich foods such as meat, fish and eggs. For this process to function efficiently, the body needs specific nutrients. Betaine anhydrous (also known as trimethylglycine or TMG), naturally found in sugar beets, acts as a methyl group donor. These methyl groups are essential for converting homocysteine back into methionine, helping to keep the body’s methylation cycle balanced.

What is SAMe?

SAMe (S-adenosylmethionine) is a biologically active compound synthesised in the body from the amino acid methionine and ATP (adenosine triphosphate). It plays a role in numerous biochemical processes, including the synthesis of glutathione. SAMe is converted into cysteine and other amino acids in a process that requires vitamin B6.

Which B vitamins are included?

In addition to betaine and SAMe, Homocystein Modulator contains the bioactive forms of vitamins B6, B12 and folate. These vitamins contribute to the maintenance of normal homocysteine metabolism and play a key role in supporting a balanced methylation process.

* The beneficial effect is obtained with a daily intake of 1.5 g of betaine.

Recommended intake

1 capsule once a day. For best results, take with a high-fat meal, washed down with 250 ml of still, lukewarm water or, alternatively, with a teaspoon of omega-3 oil to increase bioavailability.

Notes

Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of small children. Store in a cool, dry place away from light. Do not exceed the recommended daily intake.

Ingredients

Ingredients per Daily Dose NRV¹
Betaine (TMG) 700 mg  
SAMe 20 mg  
Vitamin B6 (P5P; bioactive) 15 mg 1,071
Vitamin B9 Folate (5-MTHF; bioactive) 750 µg 375
Vitamin B12 (bioactive) 900 µg 36,000
– of which Hydroxocobalamin 300 µg 12,000
– of which Adenosylcobalamin 300 µg 12,000
– of which Methylcobalamin 300 µg 12,000

1 Nutrient Reference Values for the average adult according to Regulation (EU) No. 1169/2011 (in %).

 

Composition

Betaine Anhydrous (Trimethylglycine (TMG)), coating agent: Hydroxypropyl Methylcellulose (HPMC); S-Adenosylmethionine (SAMe), Pyridoxal-5-Phosphate, Calcium Methylfolate Powder, Hydroxocobalamin Acetate, Adenosylcobalamin, Methylcobalamin.

Not a medicine.

Food supplement: Do not exceed the recommended daily intake. Not a substitute for a balanced and varied diet and a healthy lifestyle.

Pure substance principle.

No colourings, free from gluten, flavour enhancers, lactose, flavourings, soy.

Legal notice

This product is intended for nutritional purposes and is therefore not subject to the German Medicines Advertising Act (HWG). A good nutritional status can help the body to prevent or overcome diseases. All statements made about the product describe properties and physiological effects that may vary naturally among consumers and do not constitute any healing or health promises.

We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.

In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.

For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.

The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.

In the morning

Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:

  • Coenzyme Q10
  • Green tea extract
  • Certain B vitamins

Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.

Throughout the day

For some nutrients, it may be beneficial to divide the daily amount into several doses.

Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.

Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.

In the evening

Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.

In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.

With a meal

Some nutrients benefit from being taken together with a meal.

Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.

Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.

Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.

Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.

Between meals

Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:

  • Coffee and tea
  • Caffeinated beverages
  • Milk and dairy products
  • Calcium- or mineral-rich supplements

However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.

Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.

Around exercise

Proteins and amino acids can be taken both before and after training.

If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.

In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.

The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.

There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.

In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.

NatuGena Homocysteine Modulator – A premium food supplement combining betaine anhydrous (TMG), SAMe and B vitamins in a synergistic formula.
The capsules contain highly bioavailable nutrients to support optimal absorption. 90 capsules for a 3-month supply.

  • Betaine and SAMe: Provides 700 mg of high-strength betaine and 20 mg SAMe per daily serving
  • B vitamins: Includes the bioactive forms of vitamins B6, B12 and folate
  • Fast absorption: Bioavailable nutrients for rapid and efficient uptake
  • Homocysteine support: B6, B12 and folate contribute to the maintenance of normal homocysteine metabolism
  • Produced in Germany: Exceptional purity and bioavailability for optimal nutrient uptake

Homocysteine Modulator contains 700 mg of high-dose betaine, which contributes to the normal metabolism of homocysteine. Homocysteine is an amino acid naturally formed in the body during the breakdown of methionine – an essential amino acid found in protein-rich foods such as meat, fish and eggs. For this process to function efficiently, the body needs specific nutrients. Betaine anhydrous (also known as trimethylglycine or TMG), naturally found in sugar beets, acts as a methyl group donor. These methyl groups are essential for converting homocysteine back into methionine, helping to keep the body’s methylation cycle balanced.

What is SAMe?

SAMe (S-adenosylmethionine) is a biologically active compound synthesised in the body from the amino acid methionine and ATP (adenosine triphosphate). It plays a role in numerous biochemical processes, including the synthesis of glutathione. SAMe is converted into cysteine and other amino acids in a process that requires vitamin B6.

Which B vitamins are included?

In addition to betaine and SAMe, Homocystein Modulator contains the bioactive forms of vitamins B6, B12 and folate. These vitamins contribute to the maintenance of normal homocysteine metabolism and play a key role in supporting a balanced methylation process.

* The beneficial effect is obtained with a daily intake of 1.5 g of betaine.

Recommended intake

1 capsule once a day. For best results, take with a high-fat meal, washed down with 250 ml of still, lukewarm water or, alternatively, with a teaspoon of omega-3 oil to increase bioavailability.

Notes

Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of small children. Store in a cool, dry place away from light. Do not exceed the recommended daily intake.

Ingredients

Ingredients per Daily Dose NRV¹
Betaine (TMG) 700 mg  
SAMe 20 mg  
Vitamin B6 (P5P; bioactive) 15 mg 1,071
Vitamin B9 Folate (5-MTHF; bioactive) 750 µg 375
Vitamin B12 (bioactive) 900 µg 36,000
– of which Hydroxocobalamin 300 µg 12,000
– of which Adenosylcobalamin 300 µg 12,000
– of which Methylcobalamin 300 µg 12,000

1 Nutrient Reference Values for the average adult according to Regulation (EU) No. 1169/2011 (in %).

 

Composition

Betaine Anhydrous (Trimethylglycine (TMG)), coating agent: Hydroxypropyl Methylcellulose (HPMC); S-Adenosylmethionine (SAMe), Pyridoxal-5-Phosphate, Calcium Methylfolate Powder, Hydroxocobalamin Acetate, Adenosylcobalamin, Methylcobalamin.

Not a medicine.

Food supplement: Do not exceed the recommended daily intake. Not a substitute for a balanced and varied diet and a healthy lifestyle.

Pure substance principle.

No colourings, free from gluten, flavour enhancers, lactose, flavourings, soy.

Legal notice

This product is intended for nutritional purposes and is therefore not subject to the German Medicines Advertising Act (HWG). A good nutritional status can help the body to prevent or overcome diseases. All statements made about the product describe properties and physiological effects that may vary naturally among consumers and do not constitute any healing or health promises.

We work with the independent laboratory AgroLab, which we commission to perform microbiological and heavy metal tests.

In our microbiological testing, we measure the aerobic mesophilic plate count (total plate count), as well as the levels of Escherichia coli (E. coli), yeasts, Salmonella, molds, and staphylococci.

For heavy metals, we test for arsenic, lead, cadmium, and mercury in accordance with the limit values specified in Regulation (EU) 2023/915.

The optimal time to take a supplement depends on the specific nutrient, individual tolerance, and the composition of the product. However, some ingredients can be particularly well suited to certain times of day or meals.

In the morning

Stimulating ingredients are often preferably taken in the morning or during the first half of the day. These include, for example:

  • Coenzyme Q10
  • Green tea extract
  • Certain B vitamins

Especially for sensitive individuals, it may be advisable to avoid taking stimulating ingredients immediately before bedtime.

Throughout the day

For some nutrients, it may be beneficial to divide the daily amount into several doses.

Water-soluble vitamins such as B vitamins and vitamin C can be taken throughout the day.

Magnesium can also be divided into several doses rather than taking the entire daily amount at once. This may improve tolerance, particularly with higher amounts.

In the evening

Depending on the type of magnesium compound, taking it in the evening may be beneficial. Magnesium glycinate, for example, is often preferably taken in the evening.

In general, however, the best time to take a product also depends on when it is individually best tolerated and can be reliably incorporated into your daily routine.

With a meal

Some nutrients benefit from being taken together with a meal.

Fat-soluble vitamins A, D, E, and K can be taken together and ideally with a meal containing some fat.

Omega-3 fatty acids should also be taken regularly with a meal. Omega-3 oils can be combined well with fat-soluble vitamins.

Many plant-based ingredients can also be taken as part of a meal or together with omega-3 products. However, the optimal timing depends on the specific plant compound and product formulation.

Zinc can cause nausea or stomach discomfort on an empty stomach in some people. If you have a sensitive stomach, it is therefore advisable to take zinc with a meal.

Between meals

Iron is often taken separately from meals, as various foods and beverages can affect its absorption. It is particularly advisable to leave a gap between iron and:

  • Coffee and tea
  • Caffeinated beverages
  • Milk and dairy products
  • Calcium- or mineral-rich supplements

However, if you have a sensitive stomach, iron can also be taken with a meal. In this case, individual tolerance is more important than a theoretically optimal intake situation.

Enzyme supplements vary depending on their intended use: digestive enzymes are generally taken with meals. Products that are specifically intended to be taken between meals may, for example, be taken around 30 minutes before a meal. The product's specific recommended intake should always be followed.

Around exercise

Proteins and amino acids can be taken both before and after training.

If you exercise on an empty stomach, taking them around 30 minutes before training may be beneficial. If you have already eaten a protein-rich meal, you can also plan your protein intake for after training.

In general, ensuring sufficient protein intake throughout the entire day is more important than adhering to a narrow time window around your workout.

The optimal duration of use depends on the specific nutrient, your initial situation, diet, and individual requirements.

There is therefore no one-size-fits-all recommendation for how long a product should be taken. For products intended to support nutrient intake over a longer period, use over several weeks to months may be appropriate. In many cases, a period of around three months may be suitable before nutrient status and further requirements are reassessed.

In the case of diagnosed deficiencies, medical conditions, or the use of medication, the use of supplements should be individually discussed with a doctor or qualified healthcare professional.

Responsible person for the EU

The economic operator based in the EU responsible for this product:

NatuGena GmbH
Münchener Str. 149, 85051 Ingolstadt, Deutschland

+49 841 90 255 000
info@natugena.de
https://www.natugena.de (Please note: By clicking on this link, you may leave natugena.de and be redirected to an external website. Please note that we are not responsible for the content of these websites.)

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